PSA Doubling Time can be an indicator of biochemical and clinical progression. This tool predicts the changes in PSA levels over time. Pound CR, Partin AW, Eisenberger MA, Chan DW, Pearson JD, Walsh PC. Natural history of progression after PSA elevation following radical prostatectomy.
Prostate Cancer Nomograms: PSA Doubling Time This tool can be used to calculate the rate of rise of PSA, expressed as the velocity in nanograms/ml/year, or the PSA doubling time, in months or years. The most important values to enter are the date/PSA value for each PSA measured over the last 12 months.
The PSA Doubling Time Calculator calculates rate of PSA doubling in prostate cancer (correlates with survival). This is an unprecedented time. It is the dedication of healthcare workers that will lead us through this crisis.
8/10/2020 · The men had been treated between January 2007 and August 2017. The researchers divided the men’s PSA doubling times into five groups: Doubling in less than 3.
8/7/2020 · The patients’ PSA doubling times were divided into five groups, as follows: Less than 3 months; 3 to 9 months; 9 to 15 months; 15 or more months; Unknown; and the patients were then assessed for metastasis-free survival (MFS) and overall survival (OS) times in correlation with the PSA doubling times. The core findings of the study were that:, A doubling time < 6 months is considered a negative predictor, with prolonged treatment likely to be needed. PSA doubling time = ln (2) / PSA Slope; PSA Slope = (ln (PSA level 2) – ln (PSA level 1)) / Time (no. of months) The PSA velocity is the rate of PSA rise, expressed in nanograms/mL/year:, The untreated patients had a median PSA doubling time of 23 months vs 6 months for the metastatic patients. And the median onset of a rise in PSA following treatment was 20 months for the untreated patients vs 10 months for those patients who were diagnosed with metastatic disease.
